MDM4 Colorimetric Cell-Based ELISA Kit
The MDM4 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor MDM4 protein expression profile in cells. The kit can be used for measuring the relative amounts of MDM4 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on MDM4.
Product Specifications
Synonyms
Double minute 4 protein; Mdm2-like p53-binding protein; MDMX; p53-binding protein Mdm4
Gene Name
MDM4
UniProt
O15151
Reactivity
Human, Mouse, Rat
Tissue Specificity
Expressed in all tissues tested with high levels in thymus.
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.
Molecular Weight
54864 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Protein Mdm4
Subcellular Location
Nucleus.
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