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Keratin 18 Colorimetric Cell-Based ELISA Kit

The Keratin 18 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Keratin 18 protein expression profile in cells. The kit can be used for measuring the relative amounts of Keratin 18 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Keratin 18.

Product Specifications

Synonyms

CK 18; CK18; CYK18; Cytokeratin endo B; K18; K1C18; KERD; KRT1-18; KRT18; Keratin; Keratin D; Keratin; type I cytoskeletal 18; cytokeratin 18; type I cytoskeletal 18

Gene Name

KRT18

UniProt

P05783

Reactivity

Human, Mouse, Rat

Tissue Specificity

Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.

Applications

ELISA

Sample Type

Cell lines

Detection Range

> 5000 cells/well

Function

Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity) . When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6) -mediated barrier protection.

Molecular Weight

48058 MW

Shipping Conditions

Available

Storage Conditions

Store at 4°C for up to 6 months.

Other Gene Names

Keratin, type I cytoskeletal 18

Subcellular Location

Cytoplasm, perinuclear region. Nucleus, nucleolus.

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