What is the catalog number for Integrin beta3 Colorimetric Cell-Based ELISA Kit?

The catalog number for Integrin beta3 Colorimetric Cell-Based ELISA Kit is EKC1304.

What sizes are available for Integrin beta3 Colorimetric Cell-Based ELISA Kit?

Integrin beta3 Colorimetric Cell-Based ELISA Kit is available in the following size(s): 1 Kit, containing one 96 Well Plate and all necessary reagents.

Is Integrin beta3 Colorimetric Cell-Based ELISA Kit in stock?

Integrin beta3 Colorimetric Cell-Based ELISA Kit is currently made to order / not held in immediate stock. Contact us for lead time.

Where can I find the safety data sheet (SDS/MSDS) for Integrin beta3 Colorimetric Cell-Based ELISA Kit?

The safety data sheet for Integrin beta3 Colorimetric Cell-Based ELISA Kit is available here: https://www.bosterbio.com/msds?sku=EKC1304.

Integrin beta3 Colorimetric Cell-Based ELISA Kit

The Integrin beta3 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Integrin beta3 protein expression profile in cells. The kit can be used for measuring the relative amounts of Integrin beta3 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Integrin beta3.

Product Specifications

Synonyms

CD61; GP3A; GPIIIa; integrin beta-3; ITB3; platelet membrane glycoprotein IIIa

Gene Name

ITGB3

UniProt

P05106

Reactivity

Human, Mouse

Tissue Specificity

Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.

Applications

ELISA

Sample Type

Cell lines

Detection Range

> 5000 cells/well

Function

Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha- IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity) . ITGAV:ITGB3 binds to fractalkine (CX3CL1) and acts as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099) . ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778) . ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324) . ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119) . ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877) . ITGAV:ITGB3 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887) .