ICK Colorimetric Cell-Based ELISA Kit
The ICK Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor ICK protein expression profile in cells. The kit can be used for measuring the relative amounts of ICK in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on ICK.
Product Specifications
Synonyms
HICK; ICK; Intestinal cell kinase; KIAA0936; kinase ICK; Laryngeal cancer kinase 2; LCK2; MAK-related kinase; MRK; Serine/threonine kinase ICK
Gene Name
ICK
UniProt
Q9UPZ9
Reactivity
Human, Mouse, Rat
Tissue Specificity
Expressed in heart, brain, placenta, pancreas, thymus, prostate, testis, ovary, small intestine and colon, with highest levels in placenta and testis. Not detected in spleen. Also expressed in many cancer cell lines.
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Required for ciliogenesis (PubMed:24797473) . Phosphorylates KIF3A (By similarity) . Involved in the control of ciliary length (PubMed:24853502) . Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (By similarity) . May play a key role in the development of multiple organ systems and particularly in cardiac development (By similarity) . Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity (By similarity) .
Molecular Weight
71427 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Serine/threonine-protein kinase ICK
Subcellular Location
Nucleus. Cytoplasm, cytosol. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Also found at the ciliary tip (PubMed:24797473) . Nuclear localization has been observed with a GFP-tagged construct in transfected HeLa cells (PubMed:12103360, PubMed:19185282) .
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