HnRNP C1/C2 Colorimetric Cell-Based ELISA Kit
The hnRNP C1/C2 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor hnRNP C1/C2 protein expression profile in cells. The kit can be used for measuring the relative amounts of hnRNP C1/C2 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on hnRNP C1/C2.
Product Specifications
Synonyms
Heterogeneous nuclear ribonucleoproteins C1/C2; hnRNP C1 / hnRNP C2; HNRNPC; HNRPC
Gene Name
HNRNPC
UniProt
P07910
Reactivity
Human, Mouse, Rat
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621) . Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621) . Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621) . May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6- methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm (6) A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671) .
Molecular Weight
33670 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Heterogeneous nuclear ribonucleoproteins C1/C2
Subcellular Location
Nucleus. Component of ribonucleosomes.
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