HER3 Colorimetric Cell-Based ELISA Kit

The HER3 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor HER3 protein expression profile in cells. The kit can be used for measuring the relative amounts of HER3 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on HER3.

Product Specifications

Synonyms

C-erbB3; ERB3; ERBB3; HER3; kinase ErbB3; Receptor protein-tyrosine kinase erbB-3 precursor; Tyrosine kinase-type cell surface receptor HER3

Gene Name

ERBB3

UniProt

P21860

Reactivity

Human, Mouse, Rat

Tissue Specificity

Epithelial tissues and brain.

Applications

ELISA

Sample Type

Cell lines

Detection Range

> 5000 cells/well

Function

Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778) . May also be activated by CSPG5 (PubMed:15358134) .