GRK2 Colorimetric Cell-Based ELISA Kit
The GRK2 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor GRK2 protein expression profile in cells. The kit can be used for measuring the relative amounts of GRK2 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on GRK2.
Product Specifications
Synonyms
ADRBK1; ARBK1; BARK; BARK1; beta-adrenergic receptor kinase 1; beta-ARK-1; G protein receptor kinase 2; G- protein coupled receptor kinase 2; kinase GRK2
Gene Name
GRK2
UniProt
P25098
Reactivity
Human, Mouse, Rat
Tissue Specificity
Expressed in peripheral blood leukocytes.
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.
Molecular Weight
79574 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Beta-adrenergic receptor kinase 1
Subcellular Location
Cytoplasm. Cell membrane.
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