GATA4 Colorimetric Cell-Based ELISA Kit
The GATA4 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor GATA4 protein expression profile in cells. The kit can be used for measuring the relative amounts of GATA4 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on GATA4.
Product Specifications
Synonyms
DNA binding protein GATA-GT2; GAT4; GATA binding factor-4; GATA-4; Transcription factor GATA-4
Gene Name
GATA4
UniProt
P43694
Reactivity
Human, Mouse, Rat
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function (PubMed:24000169, PubMed:27984724) . In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression (PubMed:27984724) . Involved in bone morphogenetic protein (BMP) -mediated induction of cardiac- specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity) . Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity) . Promotes cardiac myocyte enlargement (PubMed:20081228) . Required during testicular development (PubMed:21220346) . May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase (PubMed:15734735) .
Molecular Weight
44565 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Transcription factor GATA-4
Subcellular Location
Nucleus.
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