Filamin A Colorimetric Cell-Based ELISA Kit
The Filamin A Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Filamin A protein expression profile in cells. The kit can be used for measuring the relative amounts of Filamin A in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Filamin A.
Product Specifications
Synonyms
ABP-280; Alpha-filamin; Endothelial actin-binding protein; FLN; FLN1; Filamin 1; Nonmuscle filamin; filamin A
Gene Name
FLNA
UniProt
P21333
Reactivity
Human, Mouse, Rat
Tissue Specificity
Ubiquitous.
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface- localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity) . Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity) .
Molecular Weight
280739 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Filamin-A
Subcellular Location
Cytoplasm, cell cortex. Cytoplasm, cytoskeleton.
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