FADD Colorimetric Cell-Based ELISA Kit
The FADD Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor FADD protein expression profile in cells. The kit can be used for measuring the relative amounts of FADD in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on FADD.
Product Specifications
Synonyms
FAS-associating death domain-containing protein; Mediator of receptor induced toxicity; MORT1
Gene Name
FADD
UniProt
Q13158
Reactivity
Human
Tissue Specificity
Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.
Molecular Weight
23279 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
FAS-associated death domain protein
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