CrkII Colorimetric Cell-Based ELISA Kit
The CrkII Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor CrkII protein expression profile in cells. The kit can be used for measuring the relative amounts of CrkII in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on CrkII.
Product Specifications
Synonyms
Adapter molecule crk; CRKO; Crk-II; P38; Proto-oncogene C-crk
Gene Name
CRK
UniProt
P46108
Reactivity
Human, Mouse, Rat
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Isoform Crk-II: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
Molecular Weight
33831 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Adapter molecule crk
Subcellular Location
Cytoplasm. Cell membrane. Translocated to the plasma membrane upon cell adhesion.
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