Connexin 43 Colorimetric Cell-Based ELISA Kit
The Connexin 43 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Connexin 43 protein expression profile in cells. The kit can be used for measuring the relative amounts of Connexin 43 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Connexin 43.
Product Specifications
Synonyms
Connexin 43; CX43; CXA1; CXN-43; Gap junction 43 kDa heart protein; Gap junction alpha-1 protein; GJA1
Gene Name
GJA1
UniProt
P17302
Reactivity
Human, Mouse, Rat
Tissue Specificity
Expressed in the heart and fetal cochlea.
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity) . May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity) .
Molecular Weight
43008 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Gap junction alpha-1 protein
Subcellular Location
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Endoplasmic reticulum. Localizes at the intercalated disk (ICD) in cardiomyocytes and the proper localization at ICD is dependent on TMEM65.
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