CD88/C5aR Colorimetric Cell-Based ELISA Kit

The CD88/C5aR Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor CD88/C5aR protein expression profile in cells. The kit can be used for measuring the relative amounts of CD88/C5aR in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on CD88/C5aR.

Product Specifications

Synonyms

C5a anaphylatoxin chemotactic receptor; C5a-R; C5AR; C5AR1; C5R1; CD88 antigen

Gene Name

C5AR1

UniProt

P21730

Reactivity

Human

Applications

ELISA

Sample Type

Cell lines

Detection Range

> 5000 cells/well

Function

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520, PubMed:29300009) . The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N- terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099) . Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520) .