Caspase 2 Colorimetric Cell-Based ELISA Kit
The Caspase 2 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Caspase 2 protein expression profile in cells. The kit can be used for measuring the relative amounts of Caspase 2 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Caspase 2.
Product Specifications
Synonyms
CASP-2; Caspase-2 precursor; ICH- 1L/1S; ICH-1 protease; ICH1
Gene Name
CASP2
UniProt
P42575
Reactivity
Human
Tissue Specificity
Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle.
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:15073321) . Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321) .
Molecular Weight
50685 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Caspase-2
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