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Calsenilin/KCNIP3 Colorimetric Cell-Based ELISA Kit

The Calsenilin/KCNIP3 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Calsenilin/KCNIP3 protein expression profile in cells. The kit can be used for measuring the relative amounts of Calsenilin/KCNIP3 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Calsenilin/KCNIP3.

Product Specifications

Synonyms

A-type potassium channel modulatory protein 3, CSEN, DRE-antagonist modulator, DREAM, KCNIP3, KChIP3, Kv channel-interacting protein 3

Gene Name

KCNIP3

UniProt

Q9Y2W7

Reactivity

Human, Mouse

Tissue Specificity

Highly expressed in brain. Widely expressed at lower levels. Expression levels are elevated in brain cortex regions affected by Alzheimer disease.

Applications

ELISA

Sample Type

Cell lines

Detection Range

> 5000 cells/well

Function

Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity) .

Molecular Weight

29231 MW

Shipping Conditions

Available

Storage Conditions

Store at 4°C for up to 6 months.

Other Gene Names

Calsenilin

Subcellular Location

Cytoplasm. Cell membrane; Lipid-anchor. Endoplasmic reticulum. Golgi apparatus. Nucleus. Also membrane-bound, associated with the plasma membrane (PubMed:15485870) . In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. The sumoylated form is present only in the nucleus.

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