Calnexin Colorimetric Cell-Based ELISA Kit
The Calnexin Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Calnexin protein expression profile in cells. The kit can be used for measuring the relative amounts of Calnexin in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Calnexin.
Product Specifications
Synonyms
CALX; CANX; IP90; Major histocompatibility complex class I
Gene Name
CANX
UniProt
P27824
Reactivity
Human, Mouse, Rat
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at the synapse.
Molecular Weight
67568 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Calnexin
Subcellular Location
Endoplasmic reticulum membrane; Single-pass type I membrane protein.Endoplasmic reticulum. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545, PubMed:17081065) . The palmitoylated form preferentially localizes to the perinuclear rough ER (PubMed:22314232) .
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