BIM Colorimetric Cell-Based ELISA Kit
The BIM Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor BIM protein expression profile in cells. The kit can be used for measuring the relative amounts of BIM in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on BIM.
Product Specifications
Synonyms
BCL2 interacting mediator of cell death; BCL2-like protein 11; BCL2L11; BOD; Bcl-2 related ovarian death protein; Bcl2 interacting mediator of cell death; Bcl2-like protein 11
Gene Name
BCL2L11
UniProt
O43521
Reactivity
Human, Mouse, Rat
Tissue Specificity
Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are widely expressed with tissue- specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney.
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.
Molecular Weight
22171 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Bcl-2-like protein 11
Subcellular Location
Endomembrane system; Peripheral membrane protein. Associated with intracytoplasmic membranes.
More Discoveries
Explore Other Products
Browse additional items from our catalog
