APAF-1-ALT Colorimetric Cell-Based ELISA Kit
The APAF-1-ALT Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor APAF-1-ALT protein expression profile in cells. The kit can be used for measuring the relative amounts of APAF-1-ALT in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on APAF-1-ALT.
Product Specifications
Synonyms
APAF1-interacting protein; APIP; APIP2; CGI-29 protein; MMRP19; dJ179L10.2; likely ortholog of mouse monocyte macrophage 19
Gene Name
APAF1
UniProt
O14727-6
Reactivity
Human
Tissue Specificity
Ubiquitous. Highest levels of expression in adult spleen and peripheral blood leukocytes, and in fetal brain, kidney and lung. Isoform 1 is expressed in heart, kidney and liver.
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.
Molecular Weight
141840 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Apoptotic protease-activating factor 1
Subcellular Location
Cytoplasm.
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