AP-2 Colorimetric Cell-Based ELISA Kit
The AP-2 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor AP-2 protein expression profile in cells. The kit can be used for measuring the relative amounts of AP-2 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on AP-2.
Product Specifications
Synonyms
AP-2; AP-2 transcription factor; AP2A; AP2TF; TFAP2; TFAP2A; activating enhancer-binding protein 2 alpha; activator protein 2
Gene Name
TFAP2A
UniProt
P05549
Reactivity
Human, Mouse, Rat
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.
Molecular Weight
48062 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Transcription factor AP-2-alpha
Subcellular Location
Nucleus.
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