AOS1 Colorimetric Cell-Based ELISA Kit
The AOS1 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor AOS1 protein expression profile in cells. The kit can be used for measuring the relative amounts of AOS1 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on AOS1.
Product Specifications
Synonyms
SUMO-activating enzyme subunit 1; Ubiquitin-like 1-activating enzyme E1A; SAE1; AOS1; SUA1; UBLE1A
Gene Name
SAE1
UniProt
Q9UBE0
Reactivity
Human, Mouse, Rat
Tissue Specificity
Expression level increases during S phase and drops in G2 phase (at protein level) .
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
Molecular Weight
38450 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
SUMO-activating enzyme subunit 1
Subcellular Location
Nucleus.
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