Anti-Phospho-Histone H4 (Ser1) HIST1H4A Rabbit Monoclonal Antibody, Clone#RM194

Histone H4; HIST1H4A; H4/A, H4FA; HIST1H4B; H4/I, H4FI; HIST1H4C; H4/G, H4FG; HIST1H4D; H4/B, H4FB; HIST1H4E; H4/J, H4FJ; HIST1H4F; H4/C, H4FC; HIST1H4H; H4/H, H4FH; HIST1H4I; H4/M, H4FM; HIST1H4J; H4/E, H4FE; HIST1H4K; H4/D, H4FD; HIST1H4L; H4/K, H4FK; HIST2H4A; H4/N, H4F2, H4FN, HIST2H4; HIST2H4B; H4/O, H4FO; HIST4H4

This antibody reacts to Histone H4 phosphorylated at Serine 1. The reactivity is not affected by neighbor Arginine 3 modification. No cross-reactivity with Histone H2A phosphorylated at Serine 1.

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.