Anti-Phospho-FAM129B (Ser679/683) Antibody

FAM129B, also known as Niban-like protein 1, belongs to a poorly characterized protein family with unknown category and function. Increased expression of the Niban gene has been observed in renal carcinomas (Adachi et al., 2004; Sun et al., 2007) . Suppression of FAM129B expression in HeLa cells has been seen to promote apoptosis, suggesting that it can modulate cell death signaling, and may be involved in the ER stress response (Sun et al., 2007) . FAM129B is also up-regulated in various types of thyroid tumors and Hashimoto’s thyroiditis (Matsumoto et al., 2006) . It has been suggested that the MAP kinase dependent phosphorylation of FAM129B is important in controlling melanoma cells, as inhibition of B/Raf/MKK/ERK in melanoma cells represses invasion (Old et al., 2009) . It is believed that phosphorylated FAM129B not only derepresses invasion, but also regulates events that promote invasion (Old et al., 2009) .

BA356B19.6 antibody, C9orf88 antibody, chromosome 9 open reading frame 88 antibody, DKFZP434H0820 antibody, FAM129B antibody, family with sequence similarity 129 member B antibody, FLJ13518 antibody, FLJ22151 antibody, FLJ22298 antibody, hypothetical protein LOC64855 antibody, Meg 3 antibody, Meg-3 antibody, Meg3 antibody, Niban like protein 1 antibody, Niban-like protein 1 antibody, NIBL1_HUMAN antibody, OC58 antibody, OTTHUMP00000022187 antibody, OTTHUMP00000022188 antibody, Protein FAM129B antibody

Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser679/683 of human FAM129B, conjugated to keyhole limpet hemocyanin (KLH) . Immunogen species is Human.

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C. After date of receipt, stable for at least 1 year at -20°C.

Specific for endogenous levels of the ~83 kDa FAM129B phosphorylated at Ser679/683. Immunolabeling is blocked by preadsorption with the phosphopeptide used as antigen, but not by the corresponding non-phosphopeptide.

Cytoplasm, cytosol. Cell junction, adherens junction. Membrane ; Lipid-anchor. In exponentially growing cells, exclusively cytoplasmic. Cell membrane localization is observed when cells reach confluency and during telophase. In melanoma cells, targeting to the plasma membrane may be impaired by C-terminal phosphorylation.