Anti-Phospho-NMDA Receptor NR2C Subunit (Ser1244) Antibody

The ion channels activated by glutamate that are sensitive to N-methyl-Daspartate (NMDA) are designated NMDA receptors (NMDAR) . The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002; Wenthold et al., 2003; Carroll and Zukin, 2002) . The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989; Alvestad et al., 2003; Snell et al., 1996) . The NMDAR is also potentiated by protein phosphorylation (Lu et al., 1999) . The NR2C subunit of the receptor is thought to influence the NMDAR conductance level (Ebralidze et al., 1996) . Phosphorylation of Ser-1244 has been shown to regulate NMDA receptor channel function (Chen et al., 2006) .

GluN2C antibody, Glutamate [NMDA] receptor subunit epsilon-3 antibody, Glutamate Receptor Ionotropic N Methyl D Aspartate 2C antibody, Glutamate receptor ionotropic NMDA 2C antibody, Glutamate receptor ionotropic N methyl D aspartate 2C antibody, Grin2c antibody, Grin 2c antibody, GRIN2C antibody, GRIN 2C antibody, N Methly D Aspartate Receptor Channel Subunit Epsilon 3 antibody, N Methyl D Aspartate Receptor Subtype 2C antibody, N methyl D aspartate receptor subunit 2C antibody, N-methyl D-aspartate receptor subtype 2C antibody, NMDAR2C antibody, NMDE3_HUMAN antibody, NR2C antibody, OTTHUMP00000041930 antibody

Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser1244 of the NR2C subunit of the rat NMDA receptor, conjugated to keyhole limpet hemocyanin (KLH) . Immunogen species is Rat.

Mainly expressed in brain with predominant expression is in the cerebellum, also present in the hippocampus, amygdala, caudate nucleus, corpus callosum, subthalamic nuclei and thalamus. Detected in the heart, skeletal muscle and pancreas.

NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C. After date of receipt, stable for at least 1 year at -20°C.

Specific for endogenous levels of the ~140 kDa NR2C subunit of the NMDA receptor phosphorylated at Ser1244. Immunolabeling is blocked by preadsorption with the phosphopeptide used as antigen, but not by the corresponding non-phosphopeptide.