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Anti-Phospho Cyclin C (Ser275) CCNC Antibody

Boster Bio Anti-Phospho Cyclin C (Ser275) CCNC Antibody (Catalog# P05832) . Tested in WB, IHC-P, IF (paraffin), ELISA applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

CCNC; Cyclin-C; SRB11 homolog; hSRB11

Gene Name

CCNC

UniProt

P24863

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A peptide derived from human Cyclin C around the phosphorylation site of Ser275. Immunogen sequence location: 234-283

Clonality

Polyclonal

Tissue Specificity

Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain.

Applications

WB, IHC-P, IF (paraffin), ELISA

Field of Research

Cell Biology, Cell Cycle, Epigenetics and Nuclear Signaling

Purification

The antibody was purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho peptide.

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.

Molecular Weight

33243 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short-term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=P05832

Product MSDS

https://www.bosterbio.com/msds?sku=P05832

Fragment

Rabbit IgG

Other Gene Names

Cyclin-C

Subcellular Location

Nucleus.

Curated Selection

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