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Anti-Phospho-AMPA Receptor (GluR 1) (Ser845) GRIA1 Rabbit Monoclonal Antibody, Clone#RM296

Boster Bio Anti-Phospho-AMPA Receptor (GluR 1) (Ser845) GRIA1 Rabbit Monoclonal Antibody, Clone#RM296 (Catalog # P02677-2) . Tested in IHC, WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

Glutamate receptor 1; GluR-1; AMPA-selective glutamate receptor 1; GluR-A; GluR-K1; Glutamate receptor ionotropic, AMPA 1; GluA1; GRIA1; GLUH1, GLUR1

Gene Name

GRIA1

UniProt

P42261

Host

Rabbit

Reactivity

Human

Cross Reactivity

Reacts to human GluR1 AMPA Receptor only when phosphorylated at Ser845. No cross-reactivity to GluR1 that is not phosphorylated at Ser845. May also react to mouse or rat Phospho-AMPA Receptor (GluR1) (Ser845) as predicted by immunogen homology.

Immunogen

A phospho-peptide corresponding to human Phospho-Glutamate Receptor 1 (GluR1) (Ser845)

Clonality

Monoclonal

Clone

Clone: RM296

Tissue Specificity

Widely expressed in brain.

Applications

IHC, WB

Field of Research

Ligand-Gated Ion Channels, Neuroscience, Neurotransmission, Receptors / Channels

Purification

Protein A affinity purified from an animal origin-free culture supernatant

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

Molecular Weight

101506 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. Avoid repeated freeze-thaw cycles.

Fragment

Rabbit IgG

Other Gene Names

Glutamate receptor 1

Subcellular Location

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, dendritic spine. Early endosome membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression. Colocalizes with PDLIM4 in early endosomes. Displays a somatodendritic localization and is excluded from axons in neurons (By similarity) .

Prediction Reactivity

Mouse, Rat

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