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Anti-Phospho-Rad17 (Ser646) Polyclonal Antibody

Boster Bio Anti-Phospho-Rad17 (Ser646) Polyclonal Antibody (Catalog # P02159) . Tested in WB, ELISA applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Cell cycle checkpoint protein RAD17; hRad17; RF-C/activator 1 homolog; RAD17; R24L

Gene Name

RAD17

UniProt

O75943

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthesized peptide derived from human Rad17 around the phosphorylation site of S646.

Clonality

Polyclonal

Tissue Specificity

Overexpressed in various cancer cell lines and in colon carcinoma (at protein level) . Isoform 2 and isoform 3 are the most abundant isoforms in non irradiated cells (at protein level) . Ubiquitous at low levels. Highly expressed in testis, where it is expressed within the germinal epithelium of the seminiferous tubuli. Weakly expressed in seminomas (testicular tumors) . .

Applications

WB, ELISA

Field of Research

DNA/RNA, DNA Damage & Repair, DNA Damage Response, Epigenetics and Nuclear Signaling

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9- HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination. .

Molecular Weight

77055 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=P02159

Product MSDS

https://www.bosterbio.com/msds?sku=P02159

Other Gene Names

Cell cycle checkpoint protein RAD17

Subcellular Location

Nucleus . Phosphorylated form redistributes to discrete nuclear foci upon DNA damage.

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