PDK1 Antibody (N-term) [APR32368G]
Product Specifications
Background
Tissue Location: Expressed predominantly in the heart. Detected at lower levels in liver, skeletal muscle and pancreas
Synonyms
[Pyruvate dehydrogenase (acetyl-transferring) ] kinase isozyme 1, mitochondrial, Pyruvate dehydrogenase kinase isoform 1, PDH kinase 1, PDK1, PDHK1
Gene Name
PDK1
Gene ID
5163
UniProt
Q15118
Chromosomal Location
Mitochondrion matrix
Applications
WB
Dilution
WB--1:1000
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Function
Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.
Molecular Weight
49244
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PDK1 Antibody (N-term) [APR32368G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=5163
Uniprot URL
https://www.uniprot.org/uniprot/Q15118
Available Sizes
Curated Selection
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