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Anti-Phospho-PERK (T981) Rabbit Polyclonal Antibody

Boster Bio Anti-Phospho-PERK (T981) Rabbit Polyclonal Antibody catalog # P01992. Tested in ELISA, IF, IHC-P, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Eukaryotic translation initiation factor 2-alpha kinase 3;2.7.11.1; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; HsPEK; EIF2AK3; PEK, PERK

Gene Name

EIF2AK3

UniProt

Q9NZJ5

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human PEK/PERK around the phosphorylation site of Thr981. AA range:947-996

Clonality

Polyclonal

Tissue Specificity

Ubiquitous. A high level expression is seen in secretory tissues.

Applications

ELISA, IF, IHC-P, WB

Purification

The antibody was affinity-purified from rabbit antiserum by affinity_x0002_chromatography using epitope-specific immunogen.

Concentration

1 mg/mL

Form

Liquid

Function

Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR) -induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) . Involved in control of mitochondrial morphology and function (By similarity) . .

Molecular Weight

125216 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

IgG

Other Gene Names

Eukaryotic translation initiation factor 2-alpha kinase 3

Subcellular Location

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

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