DL-Menthol

DL-Menthol (Racementhol) is an orally active, GABAaR positive allosteric modulator and UDP-glucuronosyltransferase (UGT) inhibitor that can cross the blood-brain barrier. DL-Menthol binds to GABAAR and exhibits an allosteric activation effect, enhancing GABA-mediated chloride influx and inhibiting neuronal excitability. DL-Menthol can induce surgical anesthesia in fish and inhibit the metabolic detoxification of tobacco carcinogens by human liver and intestinal UGT enzymes, resulting in reduced NNAL-N-Gluc production[1][2].

Product Specifications

CAS Number

[89-78-1]

Product Name Alternative

Racementhol

UNSPSC

12352211

Hazard Statement

H315, H319, H402

Target

GABA Receptor

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dl-menthol.html

Concentration

10mM

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 1 mg/mL (ultrasonic)

Smiles

C[C@H]1C[C@@H](O)[C@H](C(C)C)CC1

Molecular Formula

C10H20O

Molecular Weight

156.27

Precautions

H315, H319, H402

References & Citations

[1]Kozlovich S, et al. Role of l- and d-Menthol in the Glucuronidation and Detoxification of the Major Lung Carcinogen, NNAL. Drug Metab Dispos. 2019 Dec;47 (12) :1388-1396.|[2]Kasai, Masanori, et al. Menthol induces surgical anesthesia and rapid movement in fishes. Open Neuroscience Journal 8 (2014) : 1-8.