Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-Phospho-AFX (Ser197) FOXO4 Antibody

Boster Bio Anti-Phospho-AFX (Ser197) FOXO4 Antibody (Catalog # P01819) . Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. <br><br>Di Maira G, et al. (2005)Cell Death Differ; 12(6): 668-77. <br>Essers MA, et al. EMBO J 2004 Nov. 11. <br>Brownawell AM, (2001) Mol Cell Biol; 21(10): 3534-46. <br>Kops GJ, et al. (1999) Nature; 398(6728): 630-4.

Synonyms

Forkhead box protein O4; Fork head domain transcription factor AFX1; FOXO4; AFX, AFX1, MLLT7

Gene Name

FOXO4

UniProt

P98177

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Peptide sequence around phosphorylation site of serine 197 (A-A-S (p) -M-D) derived from Human AFX.

Clonality

Polyclonal

Tissue Specificity

Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform zeta is most abundant in the liver, kidney, and pancreas.

Applications

WB, IHC, IF

Field of Research

Domain Families, Epigenetics and Nuclear Signaling, Forkhead Box, Transcription

Purification

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Concentration

1 mg/ml

Form

Liquid

Function

Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity. .

Molecular Weight

53684 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=P01819

Product MSDS

https://www.bosterbio.com/msds?sku=P01819

Other Gene Names

Forkhead box protein O4

Subcellular Location

Cytoplasm. Nucleus. When phosphorylated, translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation. Monoubiquitination increases nuclear localization. When deubiquitinated, translocated from nucleus to cytoplasm.
Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

RGD1310358 CRISPRa sgRNA lentivector (set of three targets)(Rat)
66820126 3 x 1.0μg DNA

RGD1310358 CRISPRa sgRNA lentivector (set of three targets)(Rat)

Ask
View Details
Monoclonal Antibody to Chymotrypsin C (CTRC)
MAB310Hu22-01 20 µL

Monoclonal Antibody to Chymotrypsin C (CTRC)

Ask
View Details
Monoclonal Antibody to Chymotrypsin C (CTRC)
MAB310Hu22-02 100 µL

Monoclonal Antibody to Chymotrypsin C (CTRC)

Ask
View Details
Monoclonal Antibody to Chymotrypsin C (CTRC)
MAB310Hu22-03 200 µL

Monoclonal Antibody to Chymotrypsin C (CTRC)

Ask
View Details
Monoclonal Antibody to Chymotrypsin C (CTRC)
MAB310Hu22-04 1 mL

Monoclonal Antibody to Chymotrypsin C (CTRC)

Ask
View Details
Peanut agglutinin, PNA ELISA Kit
NSL0001PI 96 Well

Peanut agglutinin, PNA ELISA Kit

Ask
View Details