What is the catalog number for Anti-Phospho-AFX (Ser197) FOXO4 Antibody?

The catalog number for Anti-Phospho-AFX (Ser197) FOXO4 Antibody is P01819.

Is Anti-Phospho-AFX (Ser197) FOXO4 Antibody in stock?

Anti-Phospho-AFX (Ser197) FOXO4 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Where can I find the safety data sheet (SDS/MSDS) for Anti-Phospho-AFX (Ser197) FOXO4 Antibody?

The safety data sheet for Anti-Phospho-AFX (Ser197) FOXO4 Antibody is available here: https://www.bosterbio.com/msds?sku=P01819.

Anti-Phospho-AFX (Ser197) FOXO4 Antibody

Boster Bio Anti-Phospho-AFX (Ser197) FOXO4 Antibody (Catalog # P01819) . Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Di Maira G, et al. (2005)Cell Death Differ; 12(6): 668-77. Essers MA, et al. EMBO J 2004 Nov. 11. Brownawell AM, (2001) Mol Cell Biol; 21(10): 3534-46. Kops GJ, et al. (1999) Nature; 398(6728): 630-4.

Synonyms

Forkhead box protein O4; Fork head domain transcription factor AFX1; FOXO4; AFX, AFX1, MLLT7

Gene Name

FOXO4

UniProt

P98177

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Peptide sequence around phosphorylation site of serine 197 (A-A-S (p) -M-D) derived from Human AFX.

Clonality

Polyclonal

Tissue Specificity

Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform zeta is most abundant in the liver, kidney, and pancreas.

Applications

WB, IHC, IF

Field of Research

Domain Families, Epigenetics and Nuclear Signaling, Forkhead Box, Transcription

Purification

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Concentration

1 mg/ml

Form

Liquid

Function

Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity. .

Molecular Weight

53684 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Other Gene Names

Forkhead box protein O4

Subcellular Location

Cytoplasm. Nucleus. When phosphorylated, translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation. Monoubiquitination increases nuclear localization. When deubiquitinated, translocated from nucleus to cytoplasm.