Anti-Phospho-Eps15 (Y849) Antibody
Boster Bio Anti-Phospho-Eps15 (Y849) Antibody catalog # P01681. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Epidermal growth factor receptor substrate 15; Protein Eps15; Protein AF-1p; EPS15; AF1P
Gene Name
EPS15
UniProt
P42566
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized phospho-peptide around the phosphorylation site of human Eps15 (phospho Tyr849)
Tissue Specificity
Ubiquitously expressed.
Applications
WB
Purification
Immunogen affinity purified
Sensitivity
<10pg/ml
Form
Liquid
Function
Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs) . Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR) ; internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. .
Molecular Weight
98656 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Fragment
IgG
Other Gene Names
Epidermal growth factor receptor substrate 15
Subcellular Location
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Recruited to the plasma membrane upon EGFR activation and localizes to coated pits. Colocalizes with UBQLN1 in ubiquitin- rich cytoplasmic aggregates that are not endocytic compartments and in cytoplasmic juxtanuclear structures called aggresomes. .
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