Anti-Phospho-SNAP25 (Ser187) Antibody

SNAP25 (Synaptosomal associated protein of 25 kDa) is a presynaptic plasma membrane protein that is widely distributed throughout the brain and involved in the regulation of neurotransmitter release. Decreased levels of SNAP25 have been found in the brains of patients with Down Syndrome and Alzheimer’s Disease (Greber et al.,1999) . In addition, a significant reduction in the hippocampal expression of SNAP25 has also been found in patients with Schizophrenia (Fatemi et al., 2001) . Increasing evidence suggests that SNAP-25 also modulates various ion channels, including voltage gated calcium channels (VGCCs) (Pozzi el al., 2008) . Activation of PKC results in the phosphorylation of SNAP-25 on Ser-187 is believed to cause inhibition of VGCC (Pozzi el al., 2008) . Since Ser-187 phosphorylation is transiently induced by neuronal activity, SNAP25 creates a negative feedback mechanism for controlling neuronal excitability (Pozzi el al., 2008) .

BA416N4.2 antibody, Bdr antibody, CMS18 antibody, dJ1068F16.2 antibody, FLJ23079 antibody, HGNC:11132 antibody, MGC105414 antibody, MGC139754 antibody, Resistance to inhibitors of cholinesterase 4 homolog antibody, RIC 4 antibody, RIC4 antibody, SEC 9 antibody, SEC9 antibody, SNAP 25 antibody, SNAP antibody, SNAP-25 antibody, SNAP-25B antibody, SNAP25 antibody, SNP 25 antibody, SNP25 antibody, SNP25_HUMAN antibody, sp antibody, SUP antibody, Super protein antibody, Synaptosomal associated 25 kDa protein antibody, Synaptosomal associated protein antibody, Synaptosomal associated protein 25 antibody, Synaptosomal associated protein 25kDa antibody, Synaptosomal-associated 25 kDa protein antibody, Synaptosomal-associated protein 25 antibody, Synaptosomal-associated protein 25-KD antibody

Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser187 of rat SNAP25, conjugated to keyhole limpet hemocyanin (KLH) . Immunogen species is Rat.

Cancer, Cancer Metabolism, Cell Type Marker, Energy Transfer Pathways, Integration Of Energy, Integration Of Energy Metabolism, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Neuron Marker, Neuroscience, Neurotransmission, Pathways and Processes, Protein Trafficking, Secretory Vesicles, Signal Transduction, Synapse Marker, Vesicle Transport

T-SNARE involved in the molecular regulation of neurotransmitter release. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells (PubMed:12403834) . May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF.

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C. After date of receipt, stable for at least 1 year at -20°C.

Specific for endogenous levels of the ~25 kDa SNAP25 protein phosphorylated at Ser187. Immunolabeling is completely eliminated by treatment with λ-phosphatase.

Cytoplasm, perinuclear region. Cell membrane; Lipid-anchor. Cell junction, synapse, synaptosome. Cell membrane. Membrane association requires palmitoylation. Expressed throughout cytoplasm, concentrating at the perinuclear region (By similarity) . Colocalizes with KCNB1 at the cell membrane (PubMed:12403834) .