Anti-Phospho-HDAC2 (Ser394) Antibody

Histone Deacetylase 2 (HDAC2) is part of a family of histone deacetylases that are responsible for deacetylation of lysine residues in the histone core. HDAC2 is classified as a class I histone deacetylase and is ubiquitously expressed throughout the body (Kee et al, 2008) . It has been shown that HDAC2 plays an important role in cardiac hypertrophy (Eom et al, 2011) . Phosphorylation of Ser-394 is responsible for the hypertrophy-associated activation of HDAC2, whereas intrinsic basal activity is maintained by phosphorylation of Ser-422 and Ser-424 (EOM et al, 2011) .

D10Wsu179e antibody, HD 2 antibody, HD2 antibody, HDAC 2 antibody, Hdac2 antibody, HDAC2_HUMAN antibody, Histone deacetylase 2 (HD2) antibody, Histone deacetylase 2 antibody, OTTHUMP00000017046 antibody, OTTHUMP00000227077 antibody, OTTHUMP00000227078 antibody, RPD3 antibody, transcriptional regulator homolog RPD3 antibody, YAF1 antibody, YY1 associated factor 1 antibody, YY1 transcription factor binding protein antibody, Yy1bp antibody

Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser394 of human HDAC2, conjugated to keyhole limpet hemocyanin (KLH) . Immunogen species is Human.

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity) . Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA- replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C. After date of receipt, stable for at least 1 year at -20°C.

Specific for endogenous levels of the ~55 kDa HDAC2 protein phosphorylated at Ser394. Immunolabeling is completely eliminated by treatment with λ-phosphatase.