Anti-Dectin-2 CLEC6A Antibody (Monoclonal, ABM2H28)

Boster Bio Anti-Dectin-2 CLEC6A Antibody (Monoclonal, ABM2H28) (Catalog# M11863) . Tested in IHC, FACS, WB application (s) . This antibody reacts with Mouse, Human.

Product Specifications

Synonyms

C-type lectin domain family 6 member A; C-type lectin superfamily member 10; Dendritic cell-associated C-type lectin 2; DC-associated C-type lectin 2; Dectin-2; CLEC6A; CLECSF10, DECTIN2

Gene Name

CLEC6A

UniProt

Q6EIG7

Host

Mouse

Reactivity

Mouse, Human

Immunogen

A partial length recombinant Dectin-2 protein (amino acids 70-230)

Clonality

Monoclonal

Clone

Clone: ABM2H28

Tissue Specificity

Expressed in lung, spleen, lymph node, leukocytes, bone marrow, tonsils and dendritic cells. Strongly expressed in purified monocytes and weakly in B-cells. In peripheral blood cells, preferentially expressed in plasmacytoids rather than myeloids.

Applications

IHC, FACS, WB

Field of Research

Immunology, Innate Immunity, Macrophage/Inflammation

Purification

Protein G Chromatography

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Binds high-mannose carbohydrates in a Ca (2+) -dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9- NF-kappa-B-dependent pathway (By similarity) . .