Anti-Histone H3 (Unmodified Lys4) Rabbit Monoclonal Antibody, Clone#RM186

Boster Bio Anti-Histone H3 (Unmodified Lys4) Rabbit Monoclonal Antibody, Clone#RM186 (Catalog # M08865) . Tested in WB, ELISA, Luminex, ICC applications. This antibody reacts with Human, Vertebrates.

Product Specifications

Synonyms

Histone H3.1t; H3/t; H3t; H3/g; HIST3H3; H3FT

Gene Name

HIST3H3

UniProt

Q16695

Host

Rabbit

Reactivity

Human, Vertebrates

Cross Reactivity

This antibody recognizes Histone H3 that is unmodified at Lys4 but does not recognize acetylated or methylated Lys4. The antibody binding specificity allows for modifications of Arg2, Thr3, and/or other modifications in Histone H3.

Immunogen

An unmodified peptide corresponding to the N-terminus of Histone H3.

Clonality

Monoclonal

Clone

Clone: RM186

Tissue Specificity

Expressed in testicular cells.

Applications

WB, ELISA, Luminex, ICC

Field of Research

2339, Epigenetics and Nuclear Signaling, Histones

Purification

Protein A affinity purified from an animal origin-free culture supernatant

Concentration

1 mg/mL

Form

Liquid

Function

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.