Anti-MUC3 (Mucin 3) Monoclonal Antibody

Boster Bio Anti-MUC3 (Mucin 3) Monoclonal Antibody (Catalog # M08332) . Tested in Flow Cytometry, IF, IHC applications. This antibody reacts with Human.

Product Specifications

Background

This monoclonal antibody recognizes a protein of HMW, identified as mucin 3 glycoprotein (MUC3) . This monoclonal antibody shows no cross-reaction with human milk fat globule membranes, MUC1, or MUC2. The Mucins are a family of highly glycosylated, secreted proteins with a basic structure consisting of a variable number of tandem repeats (VNTRs) encoded by 60 base pairs (Mucin 1), 69 base pairs (Mucin 2) and 51 base pairs (Mucin 3) . The number of repeats is highly polymorphic and varies among different alleles. Mucin 1 proteins are expressed as type I membrane proteins in addition to secreted forms. Mucin 1 is aberrantly expressed in epithelial tumors including breast carcinomas. Mucin 2 coats the epithelia of the intestines and airways and is associated with colonic tumors. Mucin 3 is a major component of various mucus gels and is broadly expressed in normal and tumor cells.

Synonyms

Mucin-3A ; MUC-3A ; Intestinal mucin-3A ; MUC3A ; MUC3

Gene Name

MUC3A

UniProt

Q02505; Q9H195

Host

Mouse

Reactivity

Human

Immunogen

A synthetic peptide of 35 amino acids, SIB35 (C-HSTPSFTSSITTTETTSHSTPSFTSSITTTETTS), which contains two of the MUC3 tandem repeats, coupled to KLH.

Clonality

Monoclonal

Clone

Clone: Clone: MUC3/1154

Tissue Specificity

Broad specificity; small intestine, colon, colonic tumors, heart, liver, thymus, prostate, pancreas and gall bladder. .

Applications

Flow Cytometry, IF, IHC

Field of Research

Cytoskeleton/ECM, ECM Proteins, Extracellular Matrix, Signal Transduction

Purification

200ug/ml of antibody purified from Bioreactor Concentrate by Protein A/G.

Concentration

Purified antibody with BSA and azide at 200ug/ml

Form

Liquid

Function

Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling. .

Molecular Weight

345127 MW

Shipping Conditions

Available

Storage Conditions

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.