PF-05661014
PF-05661014, a desmethyl analogue of PF-06526290, selectively inhibits Nav1.3 and Nav1.7 currents by stabilizing inactivated channels via interaction with D4 VSD. PF-05661014 can be used for research of sodium channel modulation[1].
Product Specifications
CAS Number
2153474-85-0
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/pf-05661014.html
Smiles
O=S(C1=CC=C(NC(NCC2=CC=CC=C2)=O)C=C1)(NC3=NC=CS3)=O
Molecular Formula
C17H16N4O3S2
Molecular Weight
388.46
References & Citations
[1]Wang L, et al. Retracted: Addition of a single methyl group to a small molecule sodium channel inhibitor introduces a new mode of gating modulation. British Journal of Pharmacology, volume 172 (20) : 4905-4918, published in October 2015; DOI 10.1111/bph.13259. Br J Pharmacol. 2018 Jul;175 (13) :2712.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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