Anti-CD6 Monoclonal Antibody

Boster Bio Anti-CD6 Monoclonal Antibody (Catalog # M03913-1) . Tested in IF, IHC applications. This antibody reacts with Human.

Product Specifications

Background

CD6 is a type I transmembrane glycoprotein that contains a 24-amino acid signal sequence, three extracellular scavenger receptor cysteine-rich (SRCR) domains, a membrane-spanning domain and a 44-amino acid cytoplasmic domain. The CD6 glycoprotein is tyrosine phosphorylated during TCR-mediated T cell activation. CD6 shows significant homology to CD5. CD6 is present on mature thymocytes, peripheral T cells and a subset of B cells. Antibodies to CD6 are used to deplete T cells from bone marrow transplants to prevent graft versus host disease.

Synonyms

T-cell differentiation antigen CD6; T12; TP120; CD6; CD6

Gene Name

CD6

UniProt

P30203

Host

Mouse

Reactivity

Human

Immunogen

Human recombinant CD6 protein (C6/372) ; Human rheumatoid synovial T cell line ST-1 (3F7B5)

Clonality

Monoclonal

Clone

Clone: Clone: C6/372 + 3F7B5

Tissue Specificity

Expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain.

Applications

IF, IHC

Field of Research

Adaptive Immunity, Hematopoietic Progenitors, Immunology, Lymphoid, Stem Cells, T Cells, T Lymphocytic Lineage

Purification

200ug/ml of antibody purified from Bioreactor Concentrate by Protein A/G.

Concentration

Purified antibody with BSA and azide at 200ug/ml

Form

Liquid

Function

Involved in cell adhesion. Binds to CD166.

Molecular Weight

71801 MW

Shipping Conditions

Available

Storage Conditions

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.