VEGFR-2-IN-39

VEGFR-2-IN-39 (PROTAC-5) is a PROTAC targeting VEGFR-2 (IC50: 208.6 nM) . VEGFR-2-IN-39 has low toxicity.VEGFR-2-IN-39 inhibits the proliferation of EA.hy926, one of HUVECs, in a concentration-dependent manner, with an IC50 of 38.65 µM[1].

Product Specifications

CAS Number

[2353417-86-2]

UNSPSC

12352005

Target

PROTACs; VEGFR

Type

Reference compound

Related Pathways

PROTAC; Protein Tyrosine Kinase/RTK

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/vegfr-2-in-39.html

Purity

99.85

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

NC1=NN(C(CCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N2[C@@H](C[C@H](C2)O)C(NCC3=CC=C(C4=C(N=CS4)C)C=C3)=O)=O)=O)=O)C5=CC=CC(C6=CC=C(C=C6)NC(NC7=C(C=CC(C)=C7)F)=O)=C15

Molecular Formula

C55H66FN9O6S

Molecular Weight

1000.23

References & Citations

[1]Shan Y, et al. Discovery of novel anti-angiogenesis agents. Part 11: Development of PROTACs based on active molecules with potency of promoting vascular normalization. Eur J Med Chem. 2020 Nov 1;205:112654.