VEGFR-2-IN-39
Product Specifications
UNSPSC Description
VEGFR-2-IN-39 (PROTAC-5) is a PROTAC targeting VEGFR-2 (IC50: 208.6 nM). VEGFR-2-IN-39 has low toxicity.VEGFR-2-IN-39 inhibits the proliferation of EA.hy926, one of HUVECs, in a concentration-dependent manner, with an IC50 of 38.65 µM[1].
Target Antigen
PROTACs; VEGFR
Type
Reference compound
Related Pathways
PROTAC;Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/vegfr-2-in-39.html
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
NC1=NN(C(CCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N2[C@@H](C[C@H](C2)O)C(NCC3=CC=C(C4=C(N=CS4)C)C=C3)=O)=O)=O)=O)C5=CC=CC(C6=CC=C(C=C6)NC(NC7=C(C=CC(C)=C7)F)=O)=C15
Molecular Weight
1000.23
References & Citations
[1]Shan Y, et al. Discovery of novel anti-angiogenesis agents. Part 11: Development of PROTACs based on active molecules with potency of promoting vascular normalization. Eur J Med Chem. 2020 Nov 1;205:112654.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-160259/VEGFR-2-IN-39-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-160259/VEGFR-2-IN-39-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2353417-86-2
Available Sizes
Curated Selection
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