Anti-Smac/Diablo Rabbit Monoclonal Antibody, Clone#RM271

Boster Bio Anti-Smac/Diablo Rabbit Monoclonal Antibody, Clone#RM271 (Catalog # M03790-2) . Tested in IHC, WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

Diablo homolog, mitochondrial; Direct IAP-binding protein with low pI; Second mitochondria-derived activator of caspase; Smac; DIABLO; SMAC

Gene Name

DIABLO

UniProt

Q9NR28

Host

Rabbit

Reactivity

Human

Cross Reactivity

This antibody reacts to human Smac (Diablo homolog, mitochondrial) .

Immunogen

A peptide corresponding to the C-terminus of human Smac (Diablo homolog, mitochondrial) .

Clonality

Monoclonal

Clone

Clone: RM271

Tissue Specificity

Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed.

Applications

IHC, WB

Field of Research

Apoptosis, Cancer, Cell Biology, Cell Death, Invasion/Microenvironment, Metabolism, Metabolism Processes, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Pathways and Processes, Receptors

Purification

Protein A affinity purified from an animal origin-free culture supernatant

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP) . Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis- inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.