Anti- Alpha-internexin/NF66 Monoclonal Antibody

Plays a role in cell migration, axon fasciculation, and morphogenesis (PubMed:9247263) . During gonad morphogenesis, involved in distal tip cells (DTC) -mediated guidance of gonad elongation, in maintaining their sharp tapering morphology and in their migration (PubMed:19023419, PubMed:22732572) . Involved in the anterior-posterior positioning of QR neuroblast descendants by regulating the migratory speed of QR.p (PubMed:25373777) . Probably by acting as a receptor for apoptotic cells, plays a role in the clearance of apoptotic cells during mid-embryogenesis (PubMed:20226672) . .

Membrane ; Single-pass type I membrane protein . Cell projection, phagocytic cup . Cytoplasmic vesicle, phagosome membrane . Enriched at the cell contact with apoptotic cells and in phagocytic pseudopods during apoptotic cell engulfment. Co-localizes with src-1 during phagosome cup formation. .