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Anti-Fibrillarin FBL Antibody

Boster Bio Anti-Fibrillarin FBL Antibody catalog # M03178-4. Tested in IP, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

RRNA 2'-O-methyltransferase fibrillarin;2.1.1.-;34 kDa nucleolar scleroderma antigen; Histone-glutamine methyltransferase; FBL; FIB1, FLRN

Gene Name

FBL

UniProt

P22087

Host

Rabbit

Reactivity

Human, Rat, Mouse

Immunogen

Full length human fibrillarin expressed in and purified from E.Coli

Clonality

Polyclonal

Applications

IP, IHC, WB, IF, ICC

Field of Research

Actin Assembly, Actin, etc., Cytoskeleton, Cytoskeleton/ECM, Extracellular Matrix, Microfilaments, Signal Transduction, Structures

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Dilution

Western blot: 1:2,000-1:5,000. ICC/IF: 1:2,000-1:5,000.

Function

S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239) . .

Molecular Weight

33784 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=M03178-4

Product MSDS

https://www.bosterbio.com/msds?sku=M03178-4

Other Gene Names

RRNA 2'-O-methyltransferase fibrillarin

Subcellular Location

Nucleus, nucleolus . Fibrillar region of the nucleolus.

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