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Anti-Fibrillarin FBL Monoclonal Antibody

Boster Bio Anti-Fibrillarin FBL Monoclonal Antibody catalog # M03178-3. Tested in IF, IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

RRNA 2'-O-methyltransferase fibrillarin;2.1.1.-;34 kDa nucleolar scleroderma antigen; Histone-glutamine methyltransferase; FBL; FIB1, FLRN

Gene Name

FBL

UniProt

P22087

Host

Mouse

Reactivity

Human, Rat, Mouse

Immunogen

E. coli.

Clonality

Monoclonal

Applications

IF, IHC, WB

Field of Research

Actin Assembly, Actin, etc., Cytoskeleton, Cytoskeleton/ECM, Extracellular Matrix, Microfilaments, Signal Transduction, Structures

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Dilution

WB: 1:500-1:1,000. IF/ICC and IHC: 1:1,000-1:5,000.

Function

S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239) . .

Molecular Weight

33784 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=M03178-3

Product MSDS

https://www.bosterbio.com/msds?sku=M03178-3

Other Gene Names

RRNA 2'-O-methyltransferase fibrillarin

Subcellular Location

Nucleus, nucleolus . Fibrillar region of the nucleolus.

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