Anti-PSMA FOLH1 Rabbit Monoclonal Antibody, Clone#RM327

Boster Bio Anti-PSMA FOLH1 Rabbit Monoclonal Antibody, Clone#RM327 (Catalog # M02846-1) . Tested in IHC, WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

Glutamate carboxypeptidase 2;3.4.17.21; Cell growth-inhibiting gene 27 protein; Folate hydrolase 1; Folylpoly-gamma-glutamate carboxypeptidase; FGCP; Glutamate carboxypeptidase II; GCPII; Membrane glutamate carboxypeptidase; mGCP; N-acetylated-alpha-linked acidic dipeptidase I; NAALADase I; Prostate-specific membrane antigen; PSM; PSMA; Pteroylpoly-gamma-glutamate carboxypeptidase; FOLH1; FOLH, NAALAD1, PSM, PSMA; GIG27

Gene Name

FOLH1

UniProt

Q04609

Host

Rabbit

Reactivity

Human

Cross Reactivity

This antibody reacts to human PSMA (Prostate-specific membrane antigen) .

Immunogen

A peptide corresponding to the C-terminus of human PSMA (Prostate-specific membrane antigen) .

Clonality

Monoclonal

Clone

Clone: RM327

Tissue Specificity

Highly expressed in prostate epithelium. Detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon and brain (at protein level) . Detected in the small intestine, brain, kidney, liver, spleen, colon, trachea, spinal cord and the capillary endothelium of a variety of tumors. Expressed specifically in jejunum brush border membranes. In the brain, highly expressed in the ventral striatum and brain stem. Also expressed in fetal liver and kidney. Isoform PSMA' is the most abundant form in normal prostate. Isoform PSMA-1 is the most abundant form in primary prostate tumors. Isoform PSMA-3 is also found in normal prostate as well as in brain and liver. Isoform PSMA-9 is specifically expressed in prostate cancer.

Applications

IHC, WB

Field of Research

Amino Acid Metabolism, Amino Acids, Cancer, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction, Tumor Biomarkers

Purification

Protein A affinity purified from an animal origin-free culture supernatant

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Has both folate hydrolase and N-acetylated-alpha-linked- acidic dipeptidase (NAALADase) activity. Has a preference for tri- alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N- aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression.