Anti-SATB2 Rabbit Monoclonal Antibody, Clone#RM365

Boster Bio Anti-SATB2 Rabbit Monoclonal Antibody, Clone#RM365 (Catalog # M02588-1) . Tested in IHC, WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

DNA-binding protein SATB2; Special AT-rich sequence-binding protein 2; SATB2; KIAA1034

Gene Name

SATB2

UniProt

Q9UPW6

Host

Rabbit

Reactivity

Human

Cross Reactivity

This antibody reacts human DNA-binding protein SATB2

Immunogen

A peptide corresponding to the C-terminus of human DNA-binding protein SATB2

Clonality

Monoclonal

Clone

Clone: RM365

Tissue Specificity

High expression in adult brain, moderate expression in fetal brain, and weak expression in adult liver, kidney, and spinal cord and in select brain regions, including amygdala, corpus callosum, caudate nucleus, and hippocampus.

Applications

IHC, WB

Field of Research

Chromatin Binding Proteins, DNA/RNA Binding, Epigenetics and Nuclear Signaling, Neurogenesis, Neurology Process, Neuroscience

Purification

Protein A affinity purified from an animal origin-free culture supernatant

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper- layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.