Anti-Trap1 Monoclonal Antibody

The 90 kDa heat shock protein (HSP90) family of proteins that play an important physiological role. HSP90 is involved in numerous cellular processes but is best known for its association with signal transduction machinery. A recently cloned homolog of HSP90 is the tumor necrosis factor receptor-associated protein (TRAP1) . Like HSP90, TRAP1 is found to be associated with numerous proteins involved in diverse actions (1, 2) . Immunofluorescence data has shown TRAP1 to be localized in the mitochondria of mammalian cells. This observation and the fact that TRAP1 is shown to have a mitochondrial targeting pre-sequence strongly implicates TRAP1 as a mitochondrial matrix protein (3) .

Heat shock protein 75, Heat shock protein 75 kDa, Heat shock protein 75 kDa mitochondrial, HSP 75, HSP 90L, HSP75, HSP90L, mitochondrial, TNF receptor associated protein 1, TNFR associated protein 1, TNFR-associated protein 1, TRAP 1, TRAP-1, Trap1, TRAP1_HUMAN, Tumor necrosis factor receptor associated protein, Tumor necrosis factor type 1 receptor associated protein, Tumor necrosis factor type 1 receptor-associated protein

Apoptosis, Cancer, Cell Biology, Cell Death, Chaperones, Heat Shock Proteins, Metabolism, Metabolism Processes, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Pathways and Processes, Protein Trafficking, Signal Transduction