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Anti-VEGI (Vascular Endothelial Growth Inhibitor) TNFSF15 Monoclonal Antibody

Boster Bio Anti-VEGI (Vascular Endothelial Growth Inhibitor) TNFSF15 Monoclonal Antibody (Catalog # M02402-1) . Tested in IHC applications. This antibody reacts with Human.

Product Specifications

Background

VEGI is an anti-angiogenic cytokine that belongs to tumor necrosis factor superfamily, member 15 (TNFSF15) . This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of VEGI has been reported as a marker of poor prognosis in breast cancer.

Synonyms

Tumor necrosis factor ligand superfamily member 15; TNF ligand-related molecule 1; Vascular endothelial cell growth inhibitor; Tnfsf15; Tl1, Vegi

Gene Name

TNFSF15

UniProt

O95150

Host

Mouse

Reactivity

Human

Immunogen

Recombinant human VEGI fragment

Clonality

Monoclonal

Clone

Clone: Clone: VEGI/1283

Tissue Specificity

Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon.

Applications

IHC

Field of Research

Angiogenesis, Cardiovascular, Cytokines, Immunology, Innate Immunity, TNF Superfamily

Purification

200ug/ml of antibody purified from Bioreactor Concentrate by Protein A/G.

Concentration

Purified antibody with BSA and azide at 200ug/ml

Form

Liquid

Function

Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro) . Promotes activation of caspases and apoptosis (By similarity) . Promotes splenocyte alloactivation.

Molecular Weight

27723 MW

Shipping Conditions

Available

Storage Conditions

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=M02402-1

Product MSDS

https://www.bosterbio.com/msds?sku=M02402-1

Fragment

IgG1, kappa

Other Gene Names

Tumor necrosis factor ligand superfamily member 15

Subcellular Location

Cell Surface and Secreted

Protein Name

Tumor necrosis factor ligand superfamily member 15 (TNFSF15)

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