Anti-p120-catenin Rabbit Monoclonal Antibody, Clone#RM353

Boster Bio Anti-p120-catenin Rabbit Monoclonal Antibody, Clone#RM353 (Catalog # M02333-1) . Tested in IHC, WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

Catenin delta-1; Cadherin-associated Src substrate; CAS; p120 catenin; p120 (ctn) ; p120 (cas) ; CTNND1; KIAA0384

Gene Name

CTNND1

UniProt

O60716

Host

Rabbit

Reactivity

Human

Cross Reactivity

This antibody reacts human p120 catenin (Catenin delta-1)

Immunogen

A peptide corresponding to the C-terminus of human p120 catenin (Catenin delta-1)

Clonality

Monoclonal

Clone

Clone: RM353

Tissue Specificity

Expressed in vascular endothelium. Melanocytes and melanoma cells primarily express the long isoform 1A, whereas keratinocytes express shorter isoforms, especially 3A. The shortest isoform 4A, is detected in normal keratinocytes and melanocytes, and generally lost from cells derived from squamous cell carcinomas or melanomas. The C-terminal alternatively spliced exon B is present in the p120ctn transcripts in the colon, intestine and prostate, but lost in several tumor tissues derived from these organs.

Applications

IHC, WB

Field of Research

Actin, etc., Cytoplasmic, Cytoskeleton, Cytoskeleton/ECM, Microfilaments, Signal Transduction, Signaling Pathways, Stem Cells

Purification

Protein A affinity purified from an animal origin-free culture supernatant

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity) . Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.

Molecular Weight

108170 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. Avoid repeated freeze-thaw cycles.

Fragment

Rabbit IgG

Other Gene Names

Catenin delta-1

Subcellular Location

Cytoplasm. Nucleus. Cell membrane. Interaction with GLIS2 promotes nuclear translocation (By similarity) . Detected at cell-cell contacts (PubMed:15240885, PubMed:17047063) . NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm (PubMed:17047063) . CDH1 enhances cell membrane localization (PubMed:15240885) . Isoforms 4A and 1AB are excluded from the nucleus (PubMed:11896187) .