Anti-PSD-95 DLG4 Rabbit Monoclonal Antibody, Clone#RM288

Boster Bio Anti-PSD-95 DLG4 Rabbit Monoclonal Antibody, Clone#RM288 (Catalog # M02128-1) . Tested in IHC, WB applications. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

Disks large homolog 4; Postsynaptic density protein 95; PSD-95; Synapse-associated protein 90; SAP-90; SAP90; DLG4; PSD95

Gene Name

DLG4

UniProt

P78352

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

This antibody reacts to human and mouse PSD95. It may also react to rat PSD95, as predicted by immunogen homology

Immunogen

A peptide corresponding to the N-terminus of human PSD95

Clonality

Monoclonal

Clone

Clone: RM288

Tissue Specificity

Brain.

Applications

IHC, WB

Field of Research

Adapters, Cell Type Marker, Intracellular Signaling, Neuron Marker, Neuroscience, Neurotransmission, Synapse Marker

Purification

Protein A affinity purified from an animal origin-free culture supernatant

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression.

Molecular Weight

80495 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. Avoid repeated freeze-thaw cycles.

Fragment

Rabbit IgG

Other Gene Names

Disks large homolog 4

Subcellular Location

Cell membrane; Lipid-anchor; Cytoplasmic side. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Cytoplasm. Cell projection, axon. High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells.